Saffron is possibly safe for most people when taken by mouth as a medicine for up to 6 weeks. Some possible side effects include dry mouth, anxiety, dizziness, drowsiness, nausea, change in appetite and headache. Allergic reactions can occur in some people.
Taking large amounts of saffron by mouth is possibly unsafe. High doses can cause poisoning, including yellow appearance of the skin, eyes and mucous membranes; vomiting; dizziness; bloody diarrhea; bleeding from the nose, lips, and eyelids; numbness; and other serious side effects. Doses of 12-20 grams can cause death.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Taking saffron by mouth in amounts larger than what is normally found in food is likely safe. Larger amounts of saffron can make the uterus contract and might cause a miscarriage.
Not enough is known about the safety of using saffron during breast-feeding. Stay on the safe side and avoid use.
Bipolar disorder: Saffron seems to be able to affect mood. There is a concern that it might trigger excitability and impulsive behavior (mania) in people with bipolar disorder. Do not use saffron if you have this condition.
Allergies to Lolium, Olea (includes olive) and Salsola plant species: People who are allergic to these plants might also be allergic to saffron.
Heart conditions: Saffron might affect how fast and how strong the heart beats. Taking large amounts of saffron might worsen some heart conditions.
Low blood pressure: Saffron might lower blood pressure. Taking saffron might make blood pressure become too low in people with low blood pressure.